TPh A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TPh A (Triphenyl Compound A) 是核蛋白 pirin 的有效抑制剂，其 Ki 值为0.6 uM。TPh A 破坏 Bcl3-pirin 复合物的形成。TPh A 可作为相关的小分子工具调控细胞内的 Pirin。

TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells.

Cell Viability Assay Cell Line:MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells Concentration:0-100 μM Incubation Time:48 hours Result:Did not exert any potent cytotoxic activity against many human cancer cell lines.

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Others

Other Targets

Others

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21306-65-0

399.53

C21H21NO3S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (625.74 mM; 超声助溶 )

Cc1ccc(cc1)S(=O)(=O)\N=S(/C)c1ccc(OCc2ccccc2)cc1

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(-20℃)

With Ice Pack

≥ 2 years